Sociodemographic, Access to Care and Survival Outcomes for Patients with Mantle Cell Lymphoma: A National Cancer Database Analysis with Focus on Hispanics

Abstract

Mantle cell lymphoma (MCL) predominantly affects men and represents 3% of all non-Hodgkin’s lymphomas. Ethnicity and age at diagnosis may influence prognosis, but the differences between Hispanic (HI) and Non-Hispanic (NH) patients remain unclear. This National Cancer Database (NCDB) analysis, 2004 to 2019, evaluates how sociodemographic factors impact presentation and survival of HI versus NH patients with MCL. The study included 32,515 MCL patients, with 1,729 being HI. HI patients were diagnosed at a younger median age (65 vs. 68 years, p < 0.001) and had a higher incidence of Stage IV disease. HI patients had a higher rate of unknown/uninsured status (13% vs. 4%, p < 0.001). Despite these differences, HI patients had better survival outcomes at 2, 5, and 10 years (74%, 57%, 44% for HI vs. 72%, 54%, 36% for NH). The median survival was 7.0 years for HI versus 5.8 years for NH (p=0.00015). Propensity score matching confirmed the survival benefit for HI patients,. Likely due to their younger age and fewer comorbidities. Despite socioeconomic disadvantages, HI patients seem to access effective care, particularly at academic centers. Further research is needed to explore genetic and disease-specific factors contributing to this observed survival difference.